Greg Gerdeman, former assistant professor of Biology at Eckerd College in St. Petersburg, Florida, spoke at the Annual Meeting of the Congress of Clinical Rheumatology on cannabinoid treatment for rheumatic diseases.
BY: GREGORY L. GERDEMAN, PH.D.
Greg Gerdeman, former assistant professor of Biology at Eckerd College in St. Petersburg, Florida, spoke at the Annual Meeting of the Congress of Clinical Rheumatology. His remarks on cannabinoid treatment for rheumatic diseases can be heard here.
“Using cannabis or other sources of cannabinoids for rheumatic diseases shows a lot of preclinical promise because of the importance of the endocannabinoid system in regulating inflammation and the adaptive immune response.
“A lot of the players involved in rheumatic disease like macrophage, infiltration, and the release of pro-inflammatory cytokines, the release of interleukins that are pain sensitizers and help to lead to the chronic inflammatory pain associated with rheumatic diseases – these inflammatory cytokines are dampened down by CB2 cannabinoid receptors present on lipocytes, present on synovial fibroblast-like cells.
“In general, there is a great deal of preclinical research supporting showing that cannabinoids are generally immunosuppressive, they dampen down inflammation for example in situations of brain injury or stroke but also in the case of rheumatic diseases like rheumatoid arthritis.
“The take-home message for practicing rheumatologists: There needs to be more research. But in my view, that research needs to include research with patient populations who are already using cannabis and are seeking it. And the research structure—physicians and scientists—needs to be able to, need to be less shackled by policy so that they can research this with populations. There needs to be more preclinical research, but I think there needs to be research with patients who are using it so that they can be carefully followed and we can actually track the evidence of use that’s already going on, and in some places, with really good—positive that is—anecdotal reports of outcome from cannabis whether it’s inhaled or topical therapies.
“There’s a lot of legitimate scientific excitement about the use of cannabinoids in rheumatic disease. Doctors should be aware that it’s not going to go away, and they should support a research infrastructure for the best evidence-based medicines in cannabinoids and rheumatic disease.”
Science Abstracts on Arthritis
Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
Involvement of the endocannabinoid system in osteoarthritis
The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis